role of microrna in mesenchymal stem cells differentiation into osteoblasts

Authors

aamina shah institute of biochemistry and biotechnology, university of the punjab, lahore, pakistan

aftab ahmad school of biological sciences, university of the punjab, quaid iazam campus, lahore. pakistan; school of biological sciences, university of punjab, lahore, pakistan. postal code: 54590. tel: 092-3007402202, fax: 042-99230960

abstract

results treatments through mirnas can prove to be beneficial due to its small size, easy synthesis, targeted and quick delivery. conclusions further work is needed to be done to make mirna treatments available to large number of people suffering from various bone diseases. context mirnas can regulate the expression of genes by interfering in their mrnas, acting as key regulators of diverse cellular activities. osteoblast differentiation is an important process for skeletal developments and involves several mechanisms regulated by mirnas. the data for this article was collected from recently published peer reviewed articles on role of mirna in osteoblasts growth and differentiation. evidence acquisition in this review, our understanding of bone remodeling has been highlighted along with the summarized role of different mirna that regulate mesenchymal stem cell towards osteoblast differentiation for therapeutic purposes.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

differentiation of bovine spermatogonial stem cells into osteoblasts

spermatogonial stem cell (ssc) technologies provide multiple opportunities for research in the field of biotechnology and regenerative medicine. the therapeutic use of embryonic stem cells (escs) is restricted due to severe ethical and immunological concerns. therefore, we need a new pluripotent cell type. despite well-known role of germ cells in the gametogenesis, some facts apparently show th...

full text

Differentiation of Umbilical Cord Lining Membrane-Derived Mesenchymal Stem Cells into Endothelial-Like Cells

Background: Stem cell therapy for the treatment of vascular-related diseases through functional revascularization is one of the most important research areas in tissue engineering. The aim of this study was to investigate the in vitro differentiation of umbilical CL-MSC into endothelial lineage cells. Methods: In this study, isolated cells were characterized for expression of MSC-specific marke...

full text

Harvesting of bone marrow mesenchymal stem cells from live rats and the in vitro differentiation of bone marrow mesenchymal stem cells into neuron-like cells

In the bone marrow, there are certain populations of stem cell sources with the capacity to differentiate into several different types of cells. Ideally, cell transplants would be readily obtainable, easy to expand and bank, and capable of surviving for sufficient periods of time. Bone marrow mesenchymal stem cells (BM-MSCs) possess all of these characteristics. One of the most important benefi...

full text

Differentiation of Human Adipose Tissue-Derived Mesenchymal Stem Cells into Insulin Producing Cells Using Minimal Differentiation Factors

Background & Aims: Type 1 diabetes, or insulin-dependent diabetes, is an autoimmune disease in which pancreatic beta cells are destroyed by the immune system. Hitherto, no definite treatment has been found for this condition. Mesenchymal stem cells (MSCs) are multipotent, self-renewing cells that have the ability to differentiate into mesodermal tissues. This ability has attracted the attention...

full text

Evaluation of the role of mico-RNAs in cardiomyocytes differentiation of mesenchymal stem cells

Stem cells are a good alternative for regenerative medicine because of their characteristics such as self-renewal and differentiation potential. They are classified into different types of stem cells including embryonic stem cells, induced pluripotent stem cells, multipotent stem cells, and ultimately uni-potent stem cells. Mesenchymal stem cells extracted from adult tissues. Due to the lack of...

full text

Role of gangliosides in the differentiation of human mesenchymal-derived stem cells into osteoblasts and neuronal cells

Gangliosides are complex glycosphingolipids that are the major component of cytoplasmic cell membranes, and play a role in the control of biological processes. Human mesenchymal stem cells (hMSCs) have received considerable attention as alternative sources of adult stem cells because of their potential to differentiate into multiple cell lineages. In this study, we focus on various functional r...

full text

My Resources

Save resource for easier access later


Journal title:
razavi international journal of medicine

جلد ۱، شماره ۱، صفحات ۵-۱۰

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023